What to Expect After the Cerene Treatment

If your periods significantly disrupt your daily life and keep you close to home, you may be one of the ten million Americans who suffer from heavy periods, also known as heavy menstrual bleeding or “menorrhagia.1 A conversation with your OBGYN about treating your heavy period may include a discussion about endometrial ablation.

Gynecologists may use different techniques, including heat- and cold-based methods, to destroy the endometrium (the tissue that lines the inside of your uterus), which is often the cause of heavy bleeding and discomfort. Endometrial cryoablation uses cooling technology to reduce the heavy blood flow and painful cramping associated with heavy periods. The Cerene® Cryotherapy Device is an FDA-approved endometrial cryoablation device that can deliver effective relief for women looking to take their lives back from heavy periods. 

Relief From Heavy Periods in Just Three Steps

Cerene was designed to enhance patient comfort and convenience during and after endometrial ablation. The treatment can be performed in your doctor’s office without IV sedation or general anesthesia. The Cerene treatment involves three main steps:

  1. Device insertion. After preparing the device, measuring the length of the uterine cavity, and opening the cervix, the doctor gently inserts the Cerene Device into the uterus. Next, the doctor gradually deploys the cavity-conforming liner throughout the entire uterine cavity and completes final safety checks.
  2. Cryotherapy treatment. With the press of a button, the liner fills with nitrous oxide (cooling agent) and delivers the cryotherapy treatment while providing a natural pain-relieving effect. The ablation treatment begins in seconds with minimal patient discomfort. The cryotherapy treatment takes a total of 2.5 minutes.
  3. Device removal. Once the Cerene treatment is complete, the liner slowly deflates and the doctor gently removes the device. In total, from Cerene device insertion to removal, the treatment could take 6-7 minutes.

Relief From Heavy Periods in Just Three Steps

Because the Cerene treatment can be performed without IV sedation or general anesthesia, patients may leave shortly after the procedure. Patients should expect watery or bloody discharge for up to 4 weeks after treatment as the uterine cavity heals from the ablation. If any signs or symptoms of infection appear, patients should contact their doctor’s office immediately.

Cerene’s cryotechnology creates a well-tolerated ablation experience, with a median pain score of 2 on a 10-point scale during the treatment.2 After 24 hours, patients report a median pain score of 0 out of 10, and most return to normal activities within this time. 

Patients can expect to see an improvement in symptoms within 3 to 6 months. Additionally, birth control must be used continuously until menopause — talk to your doctor about which birth control option is right for you.

Lasting Relief From Heavy Periods

Cerene prioritizes the patient experience during every stage of treatment. This patient-centric approach not only includes a well-tolerated treatment without the need for sedation, but also extends to treatment outcomes. Cerene is clinically proven to provide effective relief for patients suffering from heavy periods. One study found that 90% of patients experience reduced blood flow, reporting normal, light, or no periods after treatment. Likewise, 86% of patients with debilitating cramping reported significantly less cramping one year after the Cerene treatment.

Ask your doctor if Cerene could help reduce your heavy periods and cramping.

Learn more at

† Patient-reported data are 1 year after treatment with durable results at 3 years

‡ Improvement reported for patients reporting severe/very severe cramping

Key Takeaways: 

  • The Cerene treatment involves three main steps: gentle device insertion, 2.5-minute cryotherapy treatment, and careful device removal.
  • Most patients report minimal to no pain after the procedure, and most return to normal activities within 24 hours.
  • 9 out 10 patients are satisfied with Cerene, and experience a reduction in period flow and cramping after the Cerene treatment

Important Safety Information

Cerene® Cryotherapy Device is indicated to ablate the endometrial lining of the uterus in premenopausal women with heavy menstrual bleeding due to benign causes for whom childbearing is complete. Pregnancy following the Cerene procedure can be dangerous; therefore, contraception must be used until menopause. The Cerene procedure is not for those who have or suspect uterine cancer; have an active genital, urinary or pelvic infection; or an IUD. There are risks and considerations associated with the use of the Cerene Cryotherapy Device. Temporary side effects may include uterine cramping, vaginal infection, and lightheadedness. For detailed benefit and risk information, consult the Cerene Instructions for Use (IFU) or your healthcare professional. Learn more >


  1. Heavy Menstrual Bleeding. (n.d.). Centers for Disease Control and Prevention. Retrieved March 21, 2023, from
  2. Curlin, H. (2022). Endometrial ablation in the office setting. Contemporary OB/GYN Journal 67(11).
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